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PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE).
Wednesday,2023-08-23 10:52 America/Los_Angeles — ecterry
| Title | PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE). |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Murphy, RA, Tintle, N, Harris, WS, Darvishian, M, Marklund, M, Virtanen, JK, Hantunen, S, de Mello, VD, Tuomilehto, J, Lindström, J, Bolt, MA, Brouwer, IA, Wood, AC, Senn, M, Redline, S, Tsai, MY, Gudnason, V, Eiriksdottir, G, Lindberg, E, Shadyab, AH, Liu, B, Carnethon, M, Uusitupa, M, Djoussé, L, Riserus, U, Lind, L, van Dam, RM, Koh, W-P, Shi, P, Siscovick, D, Lemaitre, RN, Mozaffarian, D |
| Journal | Am J Clin Nutr |
| Volume | 115 |
| Issue | 3 |
| Pagination | 864-876 |
| Date Published | 2022 Mar 04 |
| ISSN | 1938-3207 |
| Keywords | Biomarkers, Cohort Studies, Cross-Sectional Studies, Fatty Acids, Fatty Acids, Omega-3, Humans, Outcome Assessment, Health Care, Sleep |
| Abstract | <p><b>BACKGROUND: </b>n-3 and n-6 PUFAs have physiologic roles in sleep processes, but little is known regarding circulating n-3 and n-6 PUFA and sleep parameters.</p><p><b>OBJECTIVES: </b>We sought to assess associations between biomarkers of n-3 and n-6 PUFA intake with self-reported sleep duration and difficulty falling sleeping in the Fatty Acids and Outcome Research Consortium.</p><p><b>METHODS: </b>Harmonized, de novo, individual-level analyses were performed and pooled across 12 cohorts. Participants were 35-96 y old and from 5 nations. Circulating measures included α-linolenic acid (ALA), EPA, docosapentaenoic acid (DPA), DHA, EPA + DPA + DHA, linoleic acid, and arachidonic acid. Sleep duration (10 cohorts, n = 18,791) was categorized as short (≤6 h), 7-8 h (reference), or long (≥9 h). Difficulty falling asleep (8 cohorts, n = 12,500) was categorized as yes or no. Associations between PUFAs, sleep duration, and difficulty falling sleeping were assessed by cross-sectional multinomial logistic regression using standardized protocols and covariates. Cohort-specific multivariable-adjusted ORs per quintile of PUFAs were pooled with inverse-variance weighted meta-analysis.</p><p><b>RESULTS: </b>In pooled analysis adjusted for sociodemographic characteristics and health status, participants with higher very long-chain n-3 PUFAs were less likely to have long sleep duration. In the top compared with the bottom quintiles, the multivariable-adjusted ORs (95% CIs) for long sleep were 0.78 (95% CI: 0.65, 0.95) for DHA and 0.76 (95% CI: 0.63, 0.93) for EPA + DPA + DHA. Significant associations for ALA and n-6 PUFA with short sleep duration or difficulty falling sleeping were not identified.</p><p><b>CONCLUSIONS: </b>Participants with higher concentrations of very long-chain n-3 PUFAs were less likely to have long sleep duration. While objective biomarkers reduce recall bias and misclassification, the cross-sectional design limits assessment of the temporal nature of this relation. These novel findings across 12 cohorts highlight the need for experimental and biological assessments of very long-chain n-3 PUFAs and sleep duration.</p> |
| DOI | 10.1093/ajcn/nqab408 |
| Alternate Journal | Am J Clin Nutr |
| PubMed ID | 34918026 |
| PubMed Central ID | PMC8895226 |
| Grant List | R35 HL135818 / HL / NHLBI NIH HHS / United States |
ePub date:
22/03