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Plasma proteomic signature of decline in gait speed and grip strength.
Tuesday,2023-01-31 14:02 America/Los_Angeles — ecterry
| Title | Plasma proteomic signature of decline in gait speed and grip strength. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Liu, X, Pan, S, Xanthakis, V, Vasan, RS, Psaty, BM, Austin, TR, Newman, AB, Sanders, JL, Wu, C, Tracy, RP, Gerszten, RE, Odden, MC |
| Journal | Aging Cell |
| Volume | 21 |
| Issue | 12 |
| Pagination | e13736 |
| Date Published | 2022 Dec |
| ISSN | 1474-9726 |
| Keywords | Adult, Female, Gait, Hand Strength, Humans, Independent Living, Male, Proteomics, Walking Speed |
| Abstract | <p>The biological mechanisms underlying decline in physical function with age remain unclear. We examined the plasma proteomic profile associated with longitudinal changes in physical function measured by gait speed and grip strength in community-dwelling adults. We applied an aptamer-based platform to assay 1154 plasma proteins on 2854 participants (60% women, aged 76 years) in the Cardiovascular Health Study (CHS) in 1992-1993 and 1130 participants (55% women, aged 54 years) in the Framingham Offspring Study (FOS) in 1991-1995. Gait speed and grip strength were measured annually for 7 years in CHS and at cycles 7 (1998-2001) and 8 (2005-2008) in FOS. The associations of individual protein levels (log-transformed and standardized) with longitudinal changes in gait speed and grip strength in two populations were examined separately by linear mixed-effects models. Meta-analyses were implemented using random-effects models and corrected for multiple testing. We found that plasma levels of 14 and 18 proteins were associated with changes in gait speed and grip strength, respectively (corrected p < 0.05). The proteins most strongly associated with gait speed decline were GDF-15 (Meta-analytic p = 1.58 × 10 ), pleiotrophin (1.23 × 10 ), and TIMP-1 (5.97 × 10 ). For grip strength decline, the strongest associations were for carbonic anhydrase III (1.09 × 10 ), CDON (2.38 × 10 ), and SMOC1 (7.47 × 10 ). Several statistically significant proteins are involved in the inflammatory responses or antagonism of activin by follistatin pathway. These novel proteomic biomarkers and pathways should be further explored as future mechanisms and targets for age-related functional decline.</p> |
| DOI | 10.1111/acel.13736 |
| Alternate Journal | Aging Cell |
| PubMed ID | 36333824 |
| PubMed Central ID | PMC9741503 |
| Grant List | 75N92019D00031 / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States NO1-HC-25195 / HL / NHLBI NIH HHS / United States R01HL144483 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States 75N92019D00031 / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States NO1-HC-25195 / HL / NHLBI NIH HHS / United States R01HL144483 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States |
ePub date:
22/12