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Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study.
Monday,2022-10-10 15:10 America/Los_Angeles — ecterry
| Title | Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Eckhardt, CM, Balte, PP, Barr, RGraham, Bertoni, AG, Bhatt, SP, Cuttica, M, Cassano, PA, Chaves, P, Couper, D, Jacobs, DR, Kalhan, R, Kronmal, R, Lange, L, Loehr, L, London, SJ, O'Connor, GT, Rosamond, W, Sanders, J, Schwartz, JE, Shah, A, Shah, SJ, Smith, L, White, W, Yende, S, Oelsner, EC |
| Journal | Eur Heart J |
| Volume | 43 |
| Issue | 23 |
| Pagination | 2196-2208 |
| Date Published | 2022 06 14 |
| ISSN | 1522-9645 |
| Keywords | Adult, Heart Failure, Hospitalization, Humans, Lung, National Heart, Lung, and Blood Institute (U.S.), Prognosis, Risk Factors, Stroke Volume, United States |
| Abstract | <p><b>AIMS: </b>The aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF).</p><p><b>METHODS AND RESULTS: </b>Data were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Participants with self-reported baseline cardiovascular disease were excluded. Spirometry was used to define obstructive [forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.70] or restrictive (FEV1/FVC ≥0.70, FVC <80%) lung physiology. The incident HF was defined as hospitalization or death caused by HF. In a sub-set, HF events were sub-classified as HF with reduced ejection fraction (HFrEF; EF <50%) or preserved EF (HFpEF; EF ≥50%). The Fine-Gray proportional sub-distribution hazards models were adjusted for sociodemographic factors, smoking, and cardiovascular risk factors. In models of incident HF sub-types, HFrEF, HFpEF, and non-HF mortality were treated as competing risks. Among 31 677 adults, there were 3344 incident HF events over a median follow-up of 21.0 years. Of 2066 classifiable HF events, 1030 were classified as HFrEF and 1036 as HFpEF. Obstructive [adjusted hazard ratio (HR) 1.17, 95% confidence interval (CI) 1.07-1.27] and restrictive physiology (adjusted HR 1.43, 95% CI 1.27-1.62) were associated with incident HF. Obstructive and restrictive ventilatory defects were associated with HFpEF but not HFrEF. The magnitude of the association between restrictive physiology and HFpEF was similar to associations with hypertension, diabetes, and smoking.</p><p><b>CONCLUSION: </b>Lung function impairment was associated with increased risk of incident HF, and particularly incident HFpEF, independent of and to a similar extent as major known cardiovascular risk factors.</p> |
| DOI | 10.1093/eurheartj/ehac205 |
| Alternate Journal | Eur Heart J |
| PubMed ID | 35467708 |
| Grant List | K23 HL130627 / HL / NHLBI NIH HHS / United States R21 HL121457 / HL / NHLBI NIH HHS / United States R21 HL129924 / HL / NHLBI NIH HHS / United States R01 DK089174 / DK / NIDDK NIH HHS / United States R01 HL122477 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 HL093081 / HL / NHLBI NIH HHS / United States R01 HL077612 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 HL109315 / HL / NHLBI NIH HHS / United States R01 HL109301 / HL / NHLBI NIH HHS / United States R01 HL109284 / HL / NHLBI NIH HHS / United States R01 HL109282 / HL / NHLBI NIH HHS / United States R01 HL109319 / HL / NHLBI NIH HHS / United States |
ePub date:
22/06