You are here
Gait Speed Predicts Incident Disability: A Pooled Analysis.
Monday,2016-08-22 11:02 America/Los_Angeles — zdrager
| Title | Gait Speed Predicts Incident Disability: A Pooled Analysis. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Perera, S, Patel, KV, Rosano, C, Rubin, SM, Satterfield, S, Harris, T, Ensrud, K, Orwoll, E, Lee, CG, Chandler, JM, Newman, AB, Cauley, JA, Guralnik, JM, Ferrucci, L, Studenski, SA |
| Journal | J Gerontol A Biol Sci Med Sci |
| Volume | 71 |
| Issue | 1 |
| Pagination | 63-71 |
| Date Published | 2016 Jan |
| ISSN | 1758-535X |
| Keywords | Activities of Daily Living, Aged, Aged, 80 and over, Aging, Cohort Studies, Disability Evaluation, Disabled Persons, Female, Gait, Geriatric Assessment, Humans, Independent Living, Male, Mobility Limitation, Predictive Value of Tests, Prognosis, Psychomotor Performance, Risk Assessment, Risk Factors, ROC Curve, Survival Analysis, United States |
| Abstract | <p><b>BACKGROUND: </b>Functional independence with aging is an important goal for individuals and society. Simple prognostic indicators can inform health promotion and care planning, but evidence is limited by heterogeneity in measures of function.</p><p><b>METHODS: </b>We performed a pooled analysis of data from seven studies of 27,220 community-dwelling older adults aged 65 or older with baseline gait speed, followed for disability and mortality. Outcomes were incident inability or dependence on another person in bathing or dressing; and difficulty walking ¼ - ½ mile or climbing 10 steps within 3 years.</p><p><b>RESULTS: </b>Participants with faster baseline gait had lower rates of incident disability. In subgroups (defined by 0.2 m/s-wide intervals from <0.4 to ≥ 1.4 m/s) with increasingly greater gait speed, 3-year rates of bathing or dressing dependence trended from 10% to 1% in men, and from 15% to 1% in women, while mobility difficulty trended from 47% to 4% in men and 40% to 6% in women. The age-adjusted relative risk ratio per 0.1 m/s greater speed for bathing or dressing dependence in men was 0.68 (0.57-0.81) and in women: 0.74 (0.66-0.82); for mobility difficulty, men: 0.75 (0.68-0.82), women: 0.73 (0.67-0.80). Results were similar for combined disability and mortality. Effects were largely consistent across subgroups based on age, gender, race, body mass index, prior hospitalization, and selected chronic conditions. In the presence of multiple other risk factors for disability, gait speed significantly increased the area under the receiver operator characteristic curve.</p><p><b>CONCLUSION: </b>In older adults, gait speed predicts 3 year incidence of bathing or dressing dependence, mobility difficulty, and a composite outcome of disability and mortality.</p> |
| DOI | 10.1093/gerona/glv126 |
| Alternate Journal | J. Gerontol. A Biol. Sci. Med. Sci. |
| PubMed ID | 26297942 |
| PubMed Central ID | PMC4715231 |
| Grant List | HHSN268200800007C / / PHS HHS / United States HHSN268201200036C / / PHS HHS / United States IK2 CX000729 / CX / CSRD VA / United States N01-AG-6-2101 / AG / NIA NIH HHS / United States N01-AG-6-2103 / AG / NIA NIH HHS / United States N01-AG-6-2106 / AG / NIA NIH HHS / United States N01HC55222 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States NIA P30AG024827 / AG / NIA NIH HHS / United States R01 AG005394 / AG / NIA NIH HHS / United States R01 AG005394 / AG / NIA NIH HHS / United States R01 AG005407 / AG / NIA NIH HHS / United States R01 AG005407 / AG / NIA NIH HHS / United States R01 AG027574 / AG / NIA NIH HHS / United States R01 AG027574 / AG / NIA NIH HHS / United States R01 AG027576 / AG / NIA NIH HHS / United States R01 AG027576 / AG / NIA NIH HHS / United States R01 AR035582 / AR / NIAMS NIH HHS / United States R01 AR035583 / AR / NIAMS NIH HHS / United States R01 AR035584 / AR / NIAMS NIH HHS / United States R01 AR35582 / AR / NIAMS NIH HHS / United States R01 AR35583 / AR / NIAMS NIH HHS / United States R01 AR35584 / AR / NIAMS NIH HHS / United States R01-AG028050 / AG / NIA NIH HHS / United States R01-NR012459 / NR / NINR NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States U01 AG027810 / AG / NIA NIH HHS / United States U01 AG027810 / AG / NIA NIH HHS / United States U01 AG042124 / AG / NIA NIH HHS / United States U01 AG042124 / AG / NIA NIH HHS / United States U01 AG042139 / AG / NIA NIH HHS / United States U01 AG042139 / AG / NIA NIH HHS / United States U01 AG042140 / AG / NIA NIH HHS / United States U01 AG042140 / AG / NIA NIH HHS / United States U01 AG042143 / AG / NIA NIH HHS / United States U01 AG042143 / AG / NIA NIH HHS / United States U01 AG042145 / AG / NIA NIH HHS / United States U01 AG042145 / AG / NIA NIH HHS / United States U01 AG042168 / AG / NIA NIH HHS / United States U01 AR066160 / AR / NIAMS NIH HHS / United States U01 AR066160 / AR / NIAMS NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States UL1 TR000128 / TR / NCATS NIH HHS / United States |